Regulatory and Legal Scrutiny: Increased government regulation of pharmaceutical pricing and distribution practices, including potential legislative changes and ongoing litigation (e.g., opioid-related lawsuits), could negatively impact McKesson's operations and financial results.

Supply Chain Disruptions: Global supply chain vulnerabilities, including manufacturing delays, natural disasters, geopolitical events, and transportation issues, could disrupt the timely delivery of critical pharmaceuticals and medical products, impacting customer service and profitability.

Intense Competition: The pharmaceutical distribution and healthcare services markets are highly competitive, with established players and new entrants vying for market share, potentially leading to pricing pressures and reduced margins for McKesson.