HALEU Production & Commercialization Challenges: The successful ramp-up and commercialization of High-Assay, Low-Enriched Uranium (HALEU) production at the American Centrifuge Plant presents significant technical, operational, and cost challenges that could impact future revenue and profitability.

Geopolitical Supply Chain Disruptions: Global political instability, sanctions, trade policies, and conflicts could disrupt the reliable sourcing of uranium and enrichment services, or impact Centrus's ability to deliver products to international customers.

Advanced Nuclear Reactor Deployment Pace: The demand for Centrus's HALEU product is heavily reliant on the successful and timely development, licensing, and deployment of new advanced nuclear reactors, which may proceed slower than anticipated.